SIRT6 promotes mitochondrial fission and subsequent cellular invasion in ovarian cancer.

ABSTRACT: Ovarian cancer ranks fifth in terms of cancer mortality in women due to lack of early diagnosis and poor clinical management. Characteristics like high cellular proliferation, EMT and metabolic alterations contribute to oncogenicity. Cancer, being a "metabolic disorder," is governed by various key regulatory factors like metabolic enzymes, oncogenes, and tumor suppressors. Sirtuins (SIRT1-SIRT7) belong to the group of NAD⁺ deacetylase and ADP-ribosylation enzymes that function as NAD⁺ sensors and metabolic regulators. Among sirtuin orthologs, SIRT6 emerges as an important oncogenic player, although its possible mechanistic involvement in ovarian cancer advancement is still elusive. Our data indicated a higher expression of SIRT6 in ovarian cancer tissues compared with

SUBMITTER: Bandopadhyay S 

PROVIDER: S-EPMC9433826 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature