Assessment of disease activity in patients with rheumatoid arthritis using plasma tumour M2-pyruvate kinase test.

ABSTRACT:

Background

Pyruvate kinase M2 (PKM2) is an enzyme that regulates the final process of glycolysis and exists in tetrameric and dimeric forms. The dimeric form of PKM2, also known as tumour M2-PK, increases when aerobic glycolysis is augmented, a feature observed in rheumatoid arthritis (RA). We investigated whether plasma tumour M2-PK is elevated in patients with RA and whether its levels correlate with disease activity.

Methods

Plasma levels of tumour M2-PK were measured for patients with RA (n=151), those with osteoarthritis (OA) (n=37), and controls (n=37). We evaluated the association between plasma tumour M2-PK and continuous variables using Pearson's correlation analysis, and multivariate logistic regression analysis to determine the association between plasma tumour M2

SUBMITTER: Ahn SS 

PROVIDER: S-EPMC9433835 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature