Menopause, hysterectomy, menopausal hormone therapy and cause-specific mortality: cohort study of UK Biobank participants.

ABSTRACT:

Study question

What is the association between menopausal hormone therapy (MHT) and cause-specific mortality?

Summary answer

Self-reported MHT use following early natural menopause, surgical menopause or premenopausal hysterectomy is associated with a lower risk of breast cancer mortality and is not consistently associated with the risk of mortality from cardiovascular disease or other causes.

What is known already

Evidence from the Women's Health Initiative randomized controlled trials showed that the use of estrogen alone is not associated with the risk of cardiovascular mortality and is associated with a lower risk of breast cancer mortality, but evidence from the Million Women Study showed that use of estrogen alone is associated with a higher risk of breast cance

SUBMITTER: Xu Z 

PROVIDER: S-EPMC9433845 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature