Associations between epigenetic age acceleration and infertility.

ABSTRACT:

Study question

Is the use of ART, a proxy for infertility, associated with epigenetic age acceleration?

Summary answer

The epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed significantly between non-ART and ART mothers.

What is known already

Among mothers who used ART, epigenetic age acceleration may be associated with low oocyte yield and poor ovarian response. However, the difference in epigenetic age acceleration between non-ART and ART mothers (or even fathers) has not been examined.

Study design, size, duration

The Norwegian Mother, Father and Child Cohort Study (MoBa) recruited pregnant women and their partners across Norway at around 18 gestational weeks between 1999 and 2008. Approximately 95 000 mothers, 7

SUBMITTER: Lee Y 

PROVIDER: S-EPMC9433848 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature