High expression of nectin-1 indicates a poor prognosis and promotes metastasis in hepatocellular carcinoma.

ABSTRACT:

Objectives

Nectins are a new class of cell-adhesion molecules that play an important role in tumorigenesis and disease progression. The aim of this study was to investigate the prognostic and pathogenetic roles of nectins in hepatocellular carcinoma (HCC).

Methods

The expression levels of the nectin family in HCC and their role in prognosis were analyzed by bioinformatics analysis based on The Cancer Genome Atlas (TCGA) liver hepatocellular carcinoma database. The correlations between nectins and immune cells were analyzed using TIMER. The functional enrichment of the nectin-1 coexpression network was evaluated in TCGA cohort, and the expression levels of nectin-1 were detected by immunohistochemistry and Western blot analysis. A Transwell kit was used for cell migration exp

SUBMITTER: Wang X 

PROVIDER: S-EPMC9433868 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature