Threshold effect of plasma total homocysteine levels on cognitive function among hypertensive patients in China: A cross-sectional study.

ABSTRACT:

Background

Increased plasma total homocysteine (tHcy) is an influencing factor of cognitive impairment in the general population. However, studies on the relationship between the risk of cognitive impairment and plasma tHcy levels in patients with hypertension are limited. This study aimed to explore the association between plasma tHcy levels and cognitive function assessed by MMSE scores among hypertensive patients in China.

Methods

A total of 9,527 subjects from the Chinese Hypertension Registry Study participated in this study. Plasma tHcy levels were quantified by high-performance liquid chromatography using a fluorescence detector. Cognitive assessment was performed using the Mini-Mental State Examination (MMSE). Linear regression models, two piecewise linear regression

SUBMITTER: Wang L 

PROVIDER: S-EPMC9434013 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature