White matter disruptions related to inattention and autism spectrum symptoms in tuberous sclerosis complex.

ABSTRACT: Tuberous sclerosis complex is a rare genetic multisystem condition that is associated with a high prevalence of neurodevelopmental disorders such as autism and attention-deficit/hyperactivity disorder. The underlying neural mechanisms of the emergence of these symptom domains in tuberous sclerosis complex remain unclear. Here, we use fixel-based analysis of diffusion-weighted imaging, which allows for the differentiation between multiple fibre populations within a voxel, to compare white matter properties in 16 participants with tuberous sclerosis complex (aged 11-19) and 12 age and sex matched control participants. We further tested associations between white matter alterations and autism and inattention symptoms as well as cognitive ability in participants with tuberous sclerosis complex

SUBMITTER: Vanes LD 

PROVIDER: S-EPMC9434133 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature