Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex.

ABSTRACT: Sex chromosomes frequently differ from the autosomes in the frequencies of genes with sexually dimorphic or tissue-specific expression. Multiple hypotheses have been put forth to explain the unique gene content of the X chromosome, including selection against male-beneficial X-linked alleles, expression limits imposed by the haploid dosage of the X in males, and interference by the dosage compensation complex on expression in males. Here, we investigate these hypotheses by examining differential gene expression in Drosophila melanogaster following several treatments that have widespread transcriptomic effects: bacterial infection, viral infection, and abiotic stress. We found that genes that are induced (upregulated) by these biotic and abiotic treatments are frequently under-represented o

SUBMITTER: Meisel RP 

PROVIDER: S-EPMC9434221 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature