Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis.

ABSTRACT:

Background

Globally, the ages at pubertal onset for girls and boys have been decreasing during recent decades, partly attributed to excess body fat accumulation. However, a growing body of literature has recognized that endocrine disrupting chemicals (EDCs) may play an important role in this global trend, but the association has not yet been fully established.

Objective and rationale

EDCs can interfere with normal hormone function and metabolism and play a role in pubertal onset. We aimed to systematically identify and evaluate the current evidence on the timing of pubertal onset in girls and boys following prenatal or postnatal exposures to xenobiotic EDCs.

Search methods

Following PRISMA guidelines, we performed a systematic literature search of original peer-review

SUBMITTER: Uldbjerg CS 

PROVIDER: S-EPMC9434240 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature