Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models.

ABSTRACT: Hyperuricemia (serum urate >6.8 mg/dl) is associated with several cardiometabolic and renal diseases, such as gout and chronic kidney disease. Previous studies have examined the shared genetic basis of chronic kidney disease and hyperuricemia in humans either using single-variant tests or estimating whole-genome genetic correlations between the traits. Individual variants typically explain a small fraction of the genetic correlation between traits, thus the ability to map pleiotropic loci is lacking power for available sample sizes. Alternatively, whole-genome estimates of genetic correlation indicate a moderate correlation between these traits. While useful to explain the comorbidity of these traits, whole-genome genetic correlation estimates do not shed light on what regions may be im

SUBMITTER: Lupi AS 

PROVIDER: S-EPMC9434310 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature