Freezing of gait in Parkinson's disease is associated with the microstructural and functional changes of globus pallidus internus.

ABSTRACT:

Background

Freezing of gait (FOG) is a common motor symptom in advanced Parkinson's disease (PD). However, the pathophysiology mechanism of FOG is not fully understood. The purpose of this study was to investigate microstructural abnormalities in subcortical gray matter and alterations in functional connectivity of the nuclei with microstructural changes. In addition, the correlations between these microstructural and functional changes and the severity of FOG were measured.

Materials and methods

Twenty-four patients with FOG (PD-FOG), 22 PD patients without FOG (PD-nFOG), and 27 healthy controls (HC) were recruited. FOG Questionnaire (FOGQ) and Gait and Falling Questionnaire (GFQ) were assessed, and Timed Up and Go (TUG) tests were performed in PD-FOG patients. All subjects

SUBMITTER: Kou W 

PROVIDER: S-EPMC9434315 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature