Association of Preconception Thyrotropin Levels With Fecundability and Risk of Spontaneous Abortion in China.

ABSTRACT:

Importance

Abundant evidence suggests thyroid dysfunction is associated with adverse pregnancy outcomes. However, associations of preconception thyrotropin levels outside of reference range with reproductive health outcomes are not well characterized.

Objective

To evaluate the associations of preconception thyrotropin levels with time to pregnancy (TTP) and risk of spontaneous abortion (SA).

Design, setting, and participants

This population-based cohort study used data from the Chinese National Free Prepregnancy Checkups Project. Female participants aged 20 to 49 years who were trying to conceive were enrolled between January 1, 2013, and December 31, 2016, for the analysis of TTP or SA. Data were analyzed between August 1, 2020, and July 5, 2021.

Exposures

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SUBMITTER: Yang Y 

PROVIDER: S-EPMC9434356 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature