Vitamin D supplementation and risk of stroke: A meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Previous observational studies have supported the hypothesis that vitamin D supplementation protects against stroke. However, several current intervention studies contradict this observation. Therefore, we conducted a meta-analysis to investigate further the association between vitamin D supplementation and the risk of stroke.

Methods

This meta-analysis was conducted in accordance with the PRISMA statement and included all the randomized controlled trials (RCTs) that analyzed the relationship between vitamin D supplementation and the risk of stroke. A literature search strategy was established, and the following Medical Search Terms (MeSH) were used: "vitamin D," "Calcitriol," "Calcifediol," "Cholecalciferol," "25-Hydroxyvitamin D 2," "ergocalciferols," "stroke,"

SUBMITTER: Fu J 

PROVIDER: S-EPMC9434369 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature