A novel glycosyltransferase-related lncRNA signature correlates with lung adenocarcinoma prognosis.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most fatal cancers in the world. Previous studies have shown the increase in glycosylation level, and abnormal expressions of related enzymes are closely related to various cancers. Long non-coding RNAs (lncRNAs) play an important role in the proliferation, metabolism, and migration of cancer cells, but the underlying role of glycosyltransferase (GT)-related lncRNAs in LUAD remains to be elucidated.

Methods

We abstracted 14,056 lncRNAs from The Cancer Genome Atlas (TCGA) dataset and 257 GT-related genes from the Gene Set Enrichment Analysis (GSEA) database. Univariate, LASSO-penalized, and multivariate Cox regression analyses were conducted to construct a GT-related lncRNA prognosis model.

Results

A total of 2,726 GT

SUBMITTER: Bian C 

PROVIDER: S-EPMC9434379 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature