Palladium-catalyzed C-H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues.

ABSTRACT: The palladium-catalyzed oxidative C-H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported herein. This protocol provides an efficient, atom-economic and environmentally friendly approach to the synthesis of biologically important C5-alkene modified uracil/uridine-containing derivatives and pharmaceutical candidates.

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC9434382 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature