Neural Correlates of Variation in Personal Space and Social Functioning in Schizophrenia and Healthy Individuals.

ABSTRACT:

Background

Changes in the regulation of interpersonal distance, or "personal space" (PS), have been repeatedly observed in schizophrenia and, in some studies, linked to negative symptoms. However, the neurobiological basis of these impairments is poorly understood.

Methods

Personal space measurements, functional connectivity of a brain network sensitive to intrusions into PS, and symptoms of social withdrawal and anhedonia were assessed, and associations among these outcomes measured, in 33 individuals with a psychotic disorder (primarily schizophrenia [SCZ]) and 36 control subjects (CON).

Results

Personal space size was significantly higher (P = .002) and PS permeability (reflecting the capacity to tolerate intrusions into PS) was significantly lower (P = .021) in th

SUBMITTER: Zapetis SL 

PROVIDER: S-EPMC9434426 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature