Impaired Membrane Lipid Homeostasis in Schizophrenia.

ABSTRACT:

Background and hypothesis

Multiple lines of clinical, biochemical, and genetic evidence suggest that disturbances of membrane lipids and their metabolism are probably involved in the etiology of schizophrenia (SCZ). Lipids in the membrane are essential to neural development and brain function, however, their role in SCZ remains largely unexplored.

Study design

Here we investigated the lipidome of the erythrocyte membrane of 80 patients with SCZ and 40 healthy controls using ultra-performance liquid chromatography-mass spectrometry. Based on the membrane lipids profiling, we explored the potential mechanism of membrane phospholipids metabolism.

Study results

By comparing 812 quantified lipids, we found that in SCZ, membrane phosphatidylcholines and phosphatidylethanola

SUBMITTER: Li M 

PROVIDER: S-EPMC9434453 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature