Blood DNA Methylation Patterns in Older Adults With Evolving Dementia.

ABSTRACT: Dementia and cognitive disorders are major aging-associated pathologies. The prevalence and severity of these conditions are influenced by both genetic and environmental factors. Reflecting this, epigenetic alterations have been associated with each of these processes, especially at the level of DNA methylation, and such changes may help explain the observed interindividual variability in the development of the 2 pathologies. However, the importance of epigenetic alterations in explaining their etiology is unclear because little is known about the timing of when they appear. Here, using Illumina MethylationEPIC arrays, we have longitudinally analyzed the peripheral blood methylomes of cognitively healthy older adults (>70 year), some of whom went on to develop dementia while others stayed

SUBMITTER: Perez RF 

PROVIDER: S-EPMC9434456 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature