Association Between Low-Dose Methotrexate Exposure and Melanoma: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Methotrexate is widely used for the treatment of inflammatory disorders, including rheumatoid arthritis. Studies suggest that methotrexate may be associated with an increased risk of melanoma.

Objective

To determine whether methotrexate exposure is associated with an increased risk of cutaneous melanoma.

Data sources

MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to May 12, 2022, for eligible studies.

Study selection

Case-control studies, cohort studies, or randomized clinical trials (RCTs) were included if they examined the odds or risk of cutaneous melanoma in individuals exposed to low-dose methotrexate in comparison with individuals unexposed. No language limitations were appli

SUBMITTER: Yan MK 

PROVIDER: S-EPMC9434483 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature