Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 Variants.

ABSTRACT: The newly emerging SARS-CoV-2 variants are potential threat and posing new challenges for medical intervention due to high transmissibility and escaping neutralizing antibody (NAb) responses. Many of these variants have mutations in the receptor binding domain (RBD) of SARS-CoV-2 spike protein that interacts with the host cell receptor. Rapid mutation in the RBD through natural selection to improve affinity for host receptor and antibody pressure from vaccinated or infected individual will greatly impact the presently adopted strategies for developing interventions. Understanding the nature of mutations and how they impact the biophysical, biochemical and immunological properties of the RBD will help immensely to improve the intervention strategies. To understand the impact of mutation on

SUBMITTER: Khatri R 

PROVIDER: S-EPMC9434506 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature