A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma.

ABSTRACT:

Background

Ferroptosis is associated with cancer initiation and progression. However, the molecular mechanism and prognostic value of ferroptosis-related genes in lung squamous cell carcinoma (LUSC) are poorly understood.

Methods

The mRNA expression profiles, methylation data, and clinical information of patients with LUSC were downloaded from TCGA and GEO database. Ferroptosis-related differentially expressed genes (DEGs) were identified between cancerous and non-cancerous tissues, and their prognostic value was systemically investigated by bioinformatic analyses.

Results

A ferroptosis-related gene signature (ALOX5, TFRC, PHKG2, FADS2, NOX1) was constructed using multivariate Cox regression analysis and represented as a risk score. Overall survival (OS) probability w

SUBMITTER: Miao TW 

PROVIDER: S-EPMC9434561 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature