RNA-seq analysis reveals differentially expressed inflammatory chemokines in a rat retinal degeneration model induced by sodium iodate.

ABSTRACT:

Objective

Retinal degeneration (RD) is a group of serious blinding eye diseases characterized by photoreceptor cell apoptosis and progressive degeneration of retinal neurons. However, the underlying mechanism of its pathogenesis remains unclear.

Methods

In this study, retinal tissues from sodium iodate (NaIO₃)-induced RD and control rats were collected for transcriptome analysis using RNA-sequencing (RNA-seq). Analysis of white blood cell-related parameters was conducted in patients with retinitis pigmentosa (RP) and age-related cataract (ARC) patients.

Results

In total, 334 mRNAs, 77 long non-coding RNAs (lncRNAs), and 20 other RNA types were identified as differentially expressed in the retinas of NaIO₃-induced RD rats. Gene ontology (GO) and K

SUBMITTER: Chen S 

PROVIDER: S-EPMC9434683 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature