Catalyst- and Additive-Free C(sp³)-H Functionalization of (Thio)barbituric Acids via C-5 Dehydrogenative Aza-Coupling Under Ambient Conditions.

ABSTRACT: A one-pot room-temperature-based three-component reaction strategy has been accomplished to access a new series of bio-relevant barbituric/2-thiobarbituric acid hydrazones from the reaction between barbituric/2-thiobarbituric acids, primary aromatic amines, and tert-butyl nitrite in an acetonitrile solvent, without the aid of any catalysts/additives. The ambient reaction conditions can efficiently implement the C(sp³)-H functionalization of barbituric/2-thiobarbituric acids via C-5 dehydrogenative aza-coupling. The process does not require column chromatographic purification; pure products are obtained by simple filtration of the resulting reaction mixture, followed by washing the crude residue with distilled water. The catalyst-free ambient reaction conditions, op

SUBMITTER: Brahmachari G 

PROVIDER: S-EPMC9434791 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature