Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers.

ABSTRACT:

Background

African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded from the benefits of whole genome interrogation studies. Additionally, while structural variation (SV) is highly prevalent, PCa genomic studies are still biased towards small variant interrogation.

Methods

Using whole genome sequencing and best practice workflows, we performed a comprehensive analysis of SVs for 180 (predominantly Gleason score ≥ 8) prostate tumours derived from 115 African, 61 European and four ancestrally admixed patients. We investigated the landscape and relationship of somatic SVs in driving ethnic disparity (African versus European), wi

SUBMITTER: Gong T 

PROVIDER: S-EPMC9434886 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature