Cuproptosis-related lncRNA predict prognosis and immune response of lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) accounts for 50% of lung cancers, with high mortality and poor prognosis. Long non-coding RNA (lncRNA) plays a vital role in the progression of tumors. Cuproptosis is a newly discovered form of cell death that is highly investigated. Therefore, in the present study, we aimed to investigate the role of cuproptosis-related lncRNA signature in clinical prognosis prediction and immunotherapy and the relationship with drug sensitivity.

Material and methods

Genomic and clinical data were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and cuproptosis-related genes were obtained from cuproptosis-related studies. The prognostic signature was constructed by co-expression analysis and Cox regression analys

SUBMITTER: Wang F 

PROVIDER: S-EPMC9434888 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature