E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via β-catenin.

ABSTRACT:

Background

Cadherins play a pivotal role in facilitating intercellular interactions between spermatogonial progenitor cells (SPCs) and their surrounding microenvironment. Specifically, E-cadherin serves as a cellular marker of SPCs in many species. Depletion of E-cadherin in mouse SPCs showed no obvious effect on SPCs homing and spermatogenesis.

Results

Here, we investigated the regulatory role of E-cadherin in regulating SPCs fate. Specific deletion of E-cadherin in germ cells was shown to promote SPCs differentiation, evidencing by reduced PLZF⁺ population and increased c-Kit⁺ population in mouse testes. E-cadherin loss down-regulated the expression level of β-catenin, leading to the reduced β-catenin in nuclear localization for transcriptional activi

SUBMITTER: Song W 

PROVIDER: S-EPMC9434974 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature