Topical Glaucoma Therapy Is Associated With Alterations of the Ocular Surface Microbiome.

ABSTRACT:

Purpose

To investigate the ocular surface microbiome of patients with unilateral or asymmetric glaucoma being treated with topical ophthalmic medications in one eye and to determine whether microbial community changes were related to measures of ocular surface disease.

Methods

V3-V4 16S rRNA sequencing was conducted on ocular surface swabs collected from both eyes of 17 subjects: 10 patients with asymmetric/unilateral glaucoma using topical glaucoma therapy on only one eye and seven age-matched, healthy controls with no history of ocular disease or eyedrop use. Samples were categorized into three groups: patients' glaucomatous eye treated with eyedrops, patients' contralateral eye without eyedrops, and healthy control eyes. Comparisons were made for microbial diversity and c

SUBMITTER: Chang CJ 

PROVIDER: S-EPMC9434984 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature