Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug-naive first-episode schizophrenia patients with auditory verbal hallucinations.

ABSTRACT: Numerous studies indicate altered static local and long-range functional connectivity of multiple brain regions in schizophrenia patients with auditory verbal hallucinations (AVHs). However, the temporal dynamics of interhemispheric and intrahemispheric functional connectivity patterns remain unknown in schizophrenia patients with AVHs. We analyzed resting-state functional magnetic resonance imaging data for drug-naïve first-episode schizophrenia patients, 50 with AVHs and 50 without AVH (NAVH), and 50 age- and sex-matched healthy controls. Whole-brain functional connectivity was decomposed into ipsilateral and contralateral parts, and sliding-window analysis was used to calculate voxel-wise interhemispheric and intrahemispheric dynamic functional connectivity density (dFCD). Finally, the

SUBMITTER: Wei Y 

PROVIDER: S-EPMC9435010 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature