Treatment of multidrug-resistant gram-negative bacilli after solid organ transplant: Outcomes and complications.

ABSTRACT:

Background

Infections caused by multidrug-resistant gram-negative bacilli (GNB) cause significant morbidity and mortality in solid organ transplant (SOT) recipients.

Methods

We retrospectively collected data from all SOT recipients at a single center from 1 January 2007 to 15 April 2017 treated for infections caused by multi-drug-resistant GNB. This study examined the effects of specific antibiotics on nephrotoxicity, neurotoxicity, 30-day mortality, and length of stay in the hospital and intensive care unit.

Results

A total of 225 infections were identified among 143 patients. Carbapenem-sensitive organisms were present in 112 (49.8%) infections and were associated with decreased 30-day mortality (OR 0.35, 95% CI 0.16-0.75). Neurotoxicity was associated with polymyxi

SUBMITTER: Heldman MR 

PROVIDER: S-EPMC9435024 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature