Functionalized Electrospun Double-Layer Nanofibrous Scaffold for Wound Healing and Scar Inhibition.

ABSTRACT: Considerable advances have been made in developing materials that promote wound healing and inhibit scar formation in clinical settings. However, some challenges, such as cumbersome treatment processes and determination of optimal treatment time, remain unresolved. Thus, developing a multifunctional wound dressing with both wound healing and scar inhibition properties is crucial. Here, we present an integrated electrospun fibrous composite membrane (MPC12) for wound healing and scar inhibition, consisting of a quaternized chitosan-loaded inner membrane (PCQC5) and quaternized silicone-loaded outer membrane (MQP12). The inner membrane effectively coagulates blood and promotes wound healing, and the outer membrane moisturizes, resists bacteria, and inhibits scar formation. In vivo eva

SUBMITTER: Su C 

PROVIDER: S-EPMC9435051 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature