Preoperative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas.

ABSTRACT:

Background

PET with radiolabeled amino acids is used in the preoperative evaluation of patients with glial neoplasms. This study aimed to assess the role of [11C]methionine (MET) PET in assessing molecular features, tumor extent, and prognosis in newly diagnosed lower-grade gliomas (LGGs) surgically treated.

Methods

One hundred and fifty-three patients with a new diagnosis of grade 2/3 glioma who underwent surgery at our Institution and were imaged preoperatively using [11C]MET PET/CT were retrospectively included. [11C]MET PET images were qualitatively and semi-quantitatively analyzed using tumor-to-background ratio (TBR). Progression-free survival (PFS) rates were estimated using the Kaplan-Meier method and Cox proportional-hazards regression was used to test the associati

SUBMITTER: Ninatti G 

PROVIDER: S-EPMC9435504 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature