Distinct metabolic hallmarks of WHO classified adult glioma subtypes.

ABSTRACT:

Background

Gliomas are complex tumors with several genetic aberrations and diverse metabolic programs contributing to their aggressive phenotypes and poor prognoses. This study defines key metabolic features that can be used to differentiate between glioma subtypes, with potential for improved diagnostics and subtype targeted therapy.

Methods

Cross-platform global metabolomic profiling coupled with clinical, genetic, and pathological analysis of glioma tissue from 224 tumors-oligodendroglioma (n = 31), astrocytoma (n = 31) and glioblastoma (n = 162)-were performed. Identified metabolic phenotypes were evaluated in accordance with the WHO classification, IDH-mutation, 1p/19q-codeletion, WHO-grading 2-4, and MGMT promoter methylation.

Results

Distinct metabolic phenotyp

SUBMITTER: Bjorkblom B 

PROVIDER: S-EPMC9435506 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature