Evolution of Helicobacter spp: variability of virulence factors and their relationship to pathogenicity.

ABSTRACT:

Background

Virulence factors (VF) are bacteria-associated molecules that assist to colonize the host at the cellular level. Bacterial virulence is highly dynamic and specific pathogens have a broad array of VFs. The genus Helicobacter is gram-negative, microaerobic, flagellated, and mucus-inhabiting bacteria associated with gastrointestinal inflammation. To investigate about their pathogenicity, several Helicobacter species have been characterized and sequenced. Since the variability and possible origin of VF in the genus are not clear, our goal was to perform a comparative analysis of Helicobacter species in order to investigate VF variability and their evolutionary origin.

Methods

The complete genomes of 22 Helicobacter species available in NCBI

SUBMITTER: Prada CF 

PROVIDER: S-EPMC9435515 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature