A truncated peptide Spgillcin_177-189 derived from mud crab Scylla paramamosain exerting multiple antibacterial activities.

ABSTRACT: Antimicrobial peptides (AMPs) may be the most promising substitute for antibiotics due to their effective bactericidal activity and multiple antimicrobial modes against pathogenic bacteria. In this study, a new functional gene named Spgillcin was identified in Scylla paramamosain, which encoded 216 amino acids of mature peptide. In vivo, Spgillcin was dominantly expressed in the gills of male and female crabs, offering the highest expression level among all tested organs or tissues. The expression pattern of Spgillcin was significantly altered when challenged by Staphylococcus aureus, indicating a positive immune response. In vitro, a functional truncated peptide Spgillcin_177-189 derived from the amino acid sequence of Spgillcin was synthesized

SUBMITTER: Wang X 

PROVIDER: S-EPMC9435603 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature