DbEmbryo multi-omics database for analyses of synergistic regulation in early mammalian embryo development.

ABSTRACT: During early mammalian embryo development, different epigenetic marks undergo reprogramming and play crucial roles in the mediation of gene expression. Currently, several databases provide multi-omics information on early embryos. However, how interconnected epigenetic markers function together to coordinate the expression of the genetic code in a spatiotemporal manner remains difficult to analyze, markedly limiting scientific and clinical research. Here, we present dbEmbryo, an integrated and interactive multi-omics database for human and mouse early embryos. dbEmbryo integrates data on gene expression, DNA methylation, histone modifications, chromatin accessibility, and higher-order chromatin structure profiles for human and mouse early embryos. It incorporates customized analysis tools,

SUBMITTER: Huang X 

PROVIDER: S-EPMC9435744 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature