Dose rate and dose robustness for proton transmission FLASH-RT treatment in lung cancer.

ABSTRACT:

Purposes

To evaluate the plan quality and robustness of both dose and dose rate of proton pencil beam scanning (PBS) transmission FLASH delivery in lung cancer treatment.

Methods and materials

An in-house FLASH planning platform was used to optimize 10 lung cancer patients previously consecutively treated with proton stereotactic body radiation therapy (SBRT) to receive 3 and 5 transmission beams (Trx-3fds and Trx-5fds, respectively) to 34 Gy in a single fraction. Perturbation scenarios (n=12) for setup and range uncertainties (5 mm and 3.5%) were introduced, and dose-volume histogram and dose-rate-volume histogram bands were generated. Conventional proton SBRT clinical plans were used as a reference. RTOG 0915 dose metrics and 40 Gy/s dose rate coverage (V_40Gy/s)

SUBMITTER: Wei S 

PROVIDER: S-EPMC9435957 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature