The alteration of left ventricular strain in later-onset spinal muscular atrophy children.

ABSTRACT:

Background

Patients with spinal muscular atrophy (SMA) may suffer from multisystem injury, including an impaired cardiovascular system. However, M-mode echocardiography, the current dominant echocardiographic modality, is limited in the detection of myocardial injury. We considered the use of left ventricular strain imaging in detecting myocardial injury and explored the serum lipid profile related to cardiovascular disease in later-onset SMA children.

Methods

A case-control study involving 80 patients with later-onset SMA and 80 age-, gender-, and body surface area-matched control children was conducted in a single tertiary pediatric hospital in China. Data on the left ventricular strain measured using two-dimensional speckle tracking echocardiography, left ventricular func

SUBMITTER: Cui Y 

PROVIDER: S-EPMC9435971 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature