Removal of Uremic Solutes from Dialysate by Activated Carbon.

ABSTRACT:

Background and objectives

Adsorption of uremic solutes to activated carbon provides a potential means to limit dialysate volumes required for new dialysis systems. The ability of activated carbon to take up uremic solutes has, however, not been adequately assessed.

Design, setting, participants, & measurements

Graded volumes of waste dialysate collected from clinical hemodialysis treatments were passed through activated carbon blocks. Metabolomic analysis assessed the adsorption by activated carbon of a wide range of uremic solutes. Additional experiments tested the ability of the activated carbon to increase the clearance of selected solutes at low dialysate flow rates.

Results

Activated carbon initially adsorbed the majority, but not all, of 264 uremic solutes exami

SUBMITTER: Lee S 

PROVIDER: S-EPMC9435996 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature