The impact of genetic variants on BMI increase during childhood versus adulthood.

ABSTRACT:

Background

Genetic variants that predispose individuals to obesity may have differing influences during childhood versus adulthood, and additive effects of such variants are likely to occur. Our ongoing studies to identify genetic determinants of obesity in American Indians have identified 67 single-nucleotide polymorphisms (SNPs) that reproducibly associate with maximum lifetime non-diabetic body mass index (BMI). This study aimed to identify when, during the lifetime, these variants have their greatest impact on BMI increase.

Subjects/methods

A total of 5906 Native Americans of predominantly Pima Indian heritage with repeated measures of BMI between the ages of 5 and 45 years were included in this study. The association between each SNP with the rates of BMI increase durin

SUBMITTER: Hohenadel MG 

PROVIDER: S-EPMC9436007 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature