An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii.

ABSTRACT: The phylum Apicomplexa includes thousands of species of unicellular parasites that cause a wide range of human and animal diseases such as malaria and toxoplasmosis. To infect, the parasite must first initiate active movement to disseminate through tissue and invade into a host cell, and then cease moving once inside. The parasite moves by gliding on a surface, propelled by an internal cortical actomyosin-based motility apparatus. One of the most effective invaders in Apicomplexa is Toxoplasma gondii, which can infect any nucleated cell and any warm-blooded animal. During invasion, the parasite first makes contact with the host cell "head-on" with the apical complex, which features an elaborate cytoskeletal apparatus and associated structures. Here we report the identification and characte

SUBMITTER: Munera Lopez J 

PROVIDER: S-EPMC9436145 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature