Orthostatic stress response in pediatric Fontan patients and the effect of ACE inhibition.

ABSTRACT:

Background

Many cardiocirculatory mechanisms are involved in the adaptation to orthostatic stress. While these mechanisms may be impaired in Fontan patients. However, it is yet unclear how Fontan patients, who exhibit a critical fluid balance, respond to orthostatic stress. Angiotensin converting enzyme inhibitors are often prescribed to Fontan patients, but they may negatively influence orthostatic tolerance. Therefore, we evaluated the response to orthostatic stress in pediatric Fontan patients before and after treatment with enalapril.

Methods

Thirty-five Fontan patients (aged 14 years) with moderate-good systolic ventricular function without pre-existent enalapril treatment were included. Before and after a three-month enalapril treatment period, the hemodynamic response

SUBMITTER: Harteveld LM 

PROVIDER: S-EPMC9436155 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature