Visualizing novel connections and genetic similarities across diseases using a network-medicine based approach.

ABSTRACT: Understanding the genetic relationships between human disorders could lead to better treatment and prevention strategies, especially for individuals with multiple comorbidities. A common resource for studying genetic-disease relationships is the GWAS Catalog, a large and well curated repository of SNP-trait associations from various studies and populations. Some of these populations are contained within mega-biobanks such as the Million Veteran Program (MVP), which has enabled the genetic classification of several diseases in a large well-characterized and heterogeneous population. Here we aim to provide a network of the genetic relationships among diseases and to demonstrate the utility of quantifying the extent to which a given resource such as MVP has contributed to the discovery of suc

SUBMITTER: Ferolito B 

PROVIDER: S-EPMC9436158 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature