Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.

ABSTRACT: The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures (word reading, nonword reading, spelling, phoneme awareness, and nonword repetition) in samples of 13,633 to 33,959 participants aged 5 to 26 y. We identified genome-wide significant association with word reading (rs11208009, P = 1.098 × 10

SUBMITTER: Eising E 

PROVIDER: S-EPMC9436320 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature