Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures.

ABSTRACT: Triple negative breast cancer (TNBC) metastases are assumed to exhibit similar functions in different organs as in the original primary tumor. However, studies of metastasis are often limited to a comparison of metastatic tumors with primary tumors of their origin, and little is known about the adaptation to the local environment of the metastatic sites. We therefore used transcriptomic data and metabolic network analyses to investigate whether metastatic tumors adapt their metabolism to the metastatic site and found that metastatic tumors adopt a metabolic signature with some similarity to primary tumors of their destinations. The extent of adaptation, however, varies across different organs, and metastatic tumors retain metabolic signatures associated with TNBC. Our findings suggest that

SUBMITTER: Roshanzamir F 

PROVIDER: S-EPMC9436376 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature