NAD⁺ metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity.

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Astrocytes are the most abundant glial cells in the CNS, and their dysfunction contributes to the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Recent advances highlight the pivotal role of cellular metabolism in programming immune responses. However, the underlying immunometabolic mechanisms that drive astrocyte pathogenicity remain elusive. Nicotinamide adenine dinucleotide (NAD⁺) is a vital coenzyme involved in cellular redox reactions and a substrate for NAD⁺-dependent enzymes. Cellular NAD⁺ levels are dynamically controlled by synthesis and degradation, and dysregulation of this balance has been associated with infl

SUBMITTER: Meyer T 

PROVIDER: S-EPMC9436380 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature