Thrombin generation as a predictor of outcomes in patients with non-traumatic intracerebral hemorrhage.

ABSTRACT:

Background

Non-traumatic intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes and leads to a higher rate of mortality as compared to ischemic strokes. We aimed to find out whether the thrombin generation assay (TGA) could predict outcomes in patients with ICH.

Patients and methods

In this prospective, observational study, 87 consecutive patients with ICH and 164 healthy controls were included. Computed tomography (CT), detailed clinical investigation, and laboratory investigations were performed from patients on admission. TGA was performed using stored platelet poor plasma obtained on admission. Lag time, endogen thrombin potential (ETP), peak thrombin, and time to peak parameters were calculated. Short- and long-term outcomes of ICH were defined at 14 days and

SUBMITTER: Loczi L 

PROVIDER: S-EPMC9436391 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature