A randomised preclinical trial of adrenaline use during cardiac arrest in mice.

ABSTRACT:

Background

Adrenaline is routinely administered during cardiac arrest resuscitation. Using a novel murine model of cardiac arrest, this study evaluates the effects of adrenaline use on survival and end-organ injury.

Methods

A total of 58 mice, including cardiac arrest (CA) and sham (SHAM) groups received intravenous potassium chloride either as a bolus (CA) or slow infusion (SHAM), inducing ECG-confirmed asystole (in CA only) for 4-minutes prior to intravenous adrenaline (+ADR;250 ul,32 ug/ml) or saline (-ADR;250 ul) and manual chest compressions (300 BPM) for 4-minutes. Mice with return of spontaneous circulation (ROSC) were assessed at 24- or 72-h timepoints.

Results

Among animals that underwent CA, rates of ROSC (n = 21 (95 %) vs n = 14 (82 %), P</

SUBMITTER: Donner DG 

PROVIDER: S-EPMC9436797 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature