Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress.

ABSTRACT: Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9436817 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature