Contribution of the EssC ATPase to the assembly of the type 7b secretion system in Staphylococcus aureus.

ABSTRACT: Secretion systems utilize ATPase activity to facilitate the translocation of proteins into and across membranes. In bacteria, the universally conserved SecA ATPase binds a large repertoire of preproteins and interacts with the SecYEG translocon. In contrast, the type 7b secretion system (T7bSS) of Staphylococcus aureus supports the secretion of a restricted subset of proteins. T7bSSs are found in several Firmicutes as gene clusters encoding secreted WXG100 proteins and FtsK/SpoIIIE-like ATPase. In S. aureus, this ATPase is called EssC and comprises two cytosolic forkhead-associated domains (FHA_1-2), two membrane-spanning segments (TM_1-2), and four cytosolic modules named DUF (domain of unknown function) and ATPases_1-3 (D1D2D3). However, a detailed understan

SUBMITTER: Bobrovskyy M 

PROVIDER: S-EPMC9436818 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature