A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants.
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ABSTRACT:
SUBMITTER: Malik FI
PROVIDER: S-EPMC9436819 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants.
Malik Fady I FI Robertson Laura A LA Armas Danielle R DR Robbie Edward P EP Osmukhina Anna A Xu Donghong D Li Hanbin H Solomon Scott D SD
JACC. Basic to translational science 20220810 8
This phase 1, randomized, double-blind, placebo-controlled study of aficamten (formerly CK-3773274) in healthy adults identified a pharmacologically active range of doses and exposures. At doses that were pharmacologically active (single doses of ≤50 mg or daily dosing of ≤10 mg for 14 or 17 days), aficamten appeared to be safe and well tolerated. Adverse events were generally mild and no more frequent than with placebo. Pharmacokinetic assessments showed dose proportionality over the range of s ...[more]
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